Non-invasive, In Vivo Enhancement of Immune Function and Immunotherapy by use of Low Intensity Vibration

Background

A primary consequence of aging is the progressive dysfunction of the immune system, which leaves the subject population more vulnerable to infection, illness, and cancer. This dysfunction can be attributed, in part, to a reduction in T cell function, potentiating host susceptibility to chronic inflammation and infection. Currently, there is a lack of drug or device-based solutions which can effectively restore or maintain immune function in the elderly. Exercise remains the best intervention to prevent age related immune decline, but can be impractical for many elderly and immunocompromised patients. Thus, there remains a need for a cost-effective means of bolstering immune function in aging and immunocompromised populations.

Technology

Researchers at Stony Brook University developed a non-invasive method for augmenting T cell function that uses Low Intensity Vibration (LIV). The LIV signal is delivered to the subject as a high frequency, low magnitude mechanical stimulation which mimics the natural vibrations generated by the body during exercise. The method has been shown to enhance T cell function, activation, and help combat infection in an aged mouse model. LIV provides a safe, non-invasive therapeutic strategy for augmenting immune function in an increasingly aging and at-risk global population.

Advantages

• Non-invasive enhancement of T cell activation
• Reduction of T cell exhaustion
• Enhanced immunotherapy efficacy

Application

• Immune rejuvenation in aged populations
• Enhancing cancer immunotherapies
• General immune system support